1: bromobenzene With magnesium; iodine in tetrahydrofuran
Inert atmosphereReflux;
2: para-chloroacetophenone in tetrahydrofuran
T=0 - 20°C;
3: With water; ammonium chloride in tetrahydrofuran
T=0°C;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2009/203763 A1, 2009 ;
Location in patent: Page/Page column 35 ;
US 20090203763 A1