反应条件
1: N,N'-diisopropyl-O-tert-butylisourea / Ambient temperature 2: 1.) 2.5 N aq. NaOH / 1.) acetone, 0 deg C, 20 min, 2.) acetone, H2O, RT, 20 h 3: Et3N, 4-(dimethylamino)pyridine / CH2Cl2 / 2 h / Ambient temperature 4: trifluoroacetic acid / CH2Cl2 / 4 h / 0 °C View Scheme
参考文献
Hagmann; Kissinger; Shah; Finke; Dorn; Brause; Ashe; Weston; Maycock; Knight; Dellea; Fletcher; Hand; Osinga; Davies; Doherty
Journal of Medicinal Chemistry, 1993 , vol. 36, # 6 p. 771 - 777