8-氯-5-硝基-吖啶-2,9-二醇合成路线 （共 8 条）
反应条件
in methanol 120 h; Ambient temperature;
参考文献
Capps, David B.; Dunbar, James; Kesten, Suzanne R.; Shillis, Joan; Werbel, Leslie M.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 26 p. 4770 - 4778
反应条件
1: 93 percent / SnCl2*2H2O, conc. hydrochloric acid / ethanol / 6 h / Heating 2: 90 percent / conc. hydrochloric acid, NaNO2 / H2O / 4 h / Ambient temperature 3: 80 percent / N,N-dimethylacetamide (DMA) / acetone; CHCl3 / 4 h / 60 °C View Scheme
参考文献
Cholody; Martelli; Konopa
Journal of Medicinal Chemistry, 1990 , vol. 33, # 10 p. 2852 - 2856
反应条件
1.1: N,N-dimethyl-formamide / 4 h / Reflux 2.1: hydrazine hydrate / tetrahydrofuran / 24 h / 20 °C 2.2: 0.5 h / pH 3 3.1: 24 h / Reflux View Scheme
参考文献
Dunstan, Mark S.; Barnes, John; Humphries, Matthew; Whitehead, Roger C.; Bryce, Richard A.; Leys, David; Stratford, Ian J.; Nolan, Karen A.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6597 - 6611
反应条件
trichlorophosphate in 1,2-dichloro-ethane
T=90°C;
参考文献
Dunstan, Mark S.; Barnes, John; Humphries, Matthew; Whitehead, Roger C.; Bryce, Richard A.; Leys, David; Stratford, Ian J.; Nolan, Karen A.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6597 - 6611
反应条件
methanesulfonic acid in acetic acid
8 h; Heating;
参考文献
Capps, David B.; Dunbar, James; Kesten, Suzanne R.; Shillis, Joan; Werbel, Leslie M.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 26 p. 4770 - 4778
反应条件
1: 47 percent / N,N-dimethylaniline, N,N-diisopropylethylamine / 18 h / Heating
2: 62 percent / N,N-dimethylaniline, POCl3 / CHCl3 / 1.5 h / Heating
3: 84 percent / methanesulfonic acid / acetic acid / 8 h / Heating
View Scheme
参考文献
Capps, David B.; Dunbar, James; Kesten, Suzanne R.; Shillis, Joan; Werbel, Leslie M.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 26 p. 4770 - 4778
反应条件
1: 47 percent / N,N-dimethylaniline, N,N-diisopropylethylamine / 18 h / Heating
2: 62 percent / N,N-dimethylaniline, POCl3 / CHCl3 / 1.5 h / Heating
3: 84 percent / methanesulfonic acid / acetic acid / 8 h / Heating
View Scheme
参考文献
Capps, David B.; Dunbar, James; Kesten, Suzanne R.; Shillis, Joan; Werbel, Leslie M.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 26 p. 4770 - 4778
反应条件
1: sulfuric acid; nitric acid / 1 h / Heating
2: N,N-dimethyl-aniline / Inert atmosphere
3: trichlorophosphate / 1,2-dichloro-ethane / 90 °C
View Scheme
参考文献
Dunstan, Mark S.; Barnes, John; Humphries, Matthew; Whitehead, Roger C.; Bryce, Richard A.; Leys, David; Stratford, Ian J.; Nolan, Karen A.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6597 - 6611
