1-(2-甲基丙基)-4-氯-1H-咪唑并[4,5-c]喹啉合成路线 (共 18 条)
反应条件
trichlorophosphate in N,N-dimethyl-formamide T=20 - 80°C; 2.5 h;
参考文献
WO2006/70379 A1, ;
Page/Page column 9-10 ;
反应条件
sodium hydroxide in hydrogenchloride
反应条件
trichlorophosphate in dichloromethane 0.25 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 10 p. 3481 - 3491
反应条件
trichlorophosphate 1.5 h; Heating / reflux;
参考文献
US2005/165236 A1, ;
Page/Page column 7 ;
反应条件
1: H2; MgSO4 / Pt/C / ethyl acetate / 2740.88 Torr 2: 1 h / Heating 3: peracetic acid / ethanol / 2.5 h / 60 °C 4: 49 percent / POCl3 / CH2Cl2 / 0.25 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 10 p. 3481 - 3491
反应条件
1: H2; MgSO4 / Pt/C / ethyl acetate / 2585.74 Torr 2: 61 percent / toluene / 1.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 10 p. 3481 - 3491
反应条件
1: 81 percent / aq. HNO3 / propionic acid / 0.25 h / 125 °C 2: SOCl2; DMF / CH2Cl2 / 3 h / Heating 3: Et3N / CH2Cl2 / 0.25 h / Heating 4: H2; MgSO4 / Pt/C / ethyl acetate / 2740.88 Torr 5: 1 h / Heating 6: peracetic acid / ethanol / 2.5 h / 60 °C 7: 49 percent / POCl3 / CH2Cl2 / 0.25 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 10 p. 3481 - 3491
反应条件
1: POCl3; Et3N / toluene / 4 h / 80 - 90 °C 2: 17.8 g / Et3N / CH2Cl2 / 0.5 h / Heating 3: H2; MgSO4 / Pt/C / ethyl acetate / 2585.74 Torr 4: 61 percent / toluene / 1.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 10 p. 3481 - 3491
反应条件
1: SOCl2; DMF / CH2Cl2 / 3 h / Heating 2: Et3N / CH2Cl2 / 0.25 h / Heating 3: H2; MgSO4 / Pt/C / ethyl acetate / 2740.88 Torr 4: 1 h / Heating 5: peracetic acid / ethanol / 2.5 h / 60 °C 6: 49 percent / POCl3 / CH2Cl2 / 0.25 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 10 p. 3481 - 3491
反应条件
1: Et3N / CH2Cl2 / 0.25 h / Heating 2: H2; MgSO4 / Pt/C / ethyl acetate / 2740.88 Torr 3: 1 h / Heating 4: peracetic acid / ethanol / 2.5 h / 60 °C 5: 49 percent / POCl3 / CH2Cl2 / 0.25 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 10 p. 3481 - 3491