1: 1 h / Heating 2: peracetic acid / ethanol / 2.5 h / 60 °C 3: 49 percent / POCl3 / CH2Cl2 / 0.25 h / Heating 4: 82 percent / methanolic NH3 / 7 h / 150 °C View Scheme

sodium methylate in methanol 2 h; Heating;

1: 61 percent / toluene / 1.5 h / Heating 2: 82 percent / methanolic NH3 / 7 h / 150 °C View Scheme

暂无反应条件数据

1: PdCl2(PPh3)2, K2CO3, Et4N(1+)Cl(1-) / dimethylformamide / 2 h / 110 °C 2: 10percent aq. NaOH / dioxane / 12 h / Heating 3: Et3N, DPPA / benzene / 1 h / 50 °C 4: 1,2-dichloro-benzene / 1 h / Heating 5: 88 percent / POCl3 / 1 h / Heating 6: 93 percent / 28percent NH4OH / methanol / 48 h / 150 °C 7: 80 percent / sodium bis(2-methoxyethoxy)aluminium hydride / toluene / 0.5 h / Heating View Scheme

1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, RT, 12 h 2: 83 percent / NBS / CCl4 / 1 h / Ambient temperature 3: 98 percent / Pd(PPh3)4, aq. Na2CO3 / toluene; ethanol / 4 h / 110 °C 4: 98 percent / NBS / CCl4 / 1 h 5: 1.) n-BuLi / 1.) Et2O, hexane, -78 deg C, 1 h, 2.) Et2O, hexane, RT, 12 h 6: 46 percent / Et3N, PPh3, CCl4 / acetonitrile / 1.) RT, 1 h, 2.) reflux, 3 h 7: 62 percent / 1,2-dichloro-benzene / 8 h / Heating 8: 41 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / benzene / 4 h / Heating 9: 93 percent / 28percent NH4OH / methanol / 48 h / 150 °C 10: 80 percent / sodium bis(2-methoxyethoxy)aluminium hydride / toluene / 0.5 h / Heating View Scheme

1: 83 percent / NBS / CCl4 / 1 h / Ambient temperature 2: 98 percent / Pd(PPh3)4, aq. Na2CO3 / toluene; ethanol / 4 h / 110 °C 3: 98 percent / NBS / CCl4 / 1 h 4: 1.) n-BuLi / 1.) Et2O, hexane, -78 deg C, 1 h, 2.) Et2O, hexane, RT, 12 h 5: 46 percent / Et3N, PPh3, CCl4 / acetonitrile / 1.) RT, 1 h, 2.) reflux, 3 h 6: 62 percent / 1,2-dichloro-benzene / 8 h / Heating 7: 41 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / benzene / 4 h / Heating 8: 93 percent / 28percent NH4OH / methanol / 48 h / 150 °C 9: 80 percent / sodium bis(2-methoxyethoxy)aluminium hydride / toluene / 0.5 h / Heating View Scheme

1: 98 percent / Pd(PPh3)4, aq. Na2CO3 / toluene; ethanol / 4 h / 110 °C 2: 98 percent / NBS / CCl4 / 1 h 3: 1.) n-BuLi / 1.) Et2O, hexane, -78 deg C, 1 h, 2.) Et2O, hexane, RT, 12 h 4: 46 percent / Et3N, PPh3, CCl4 / acetonitrile / 1.) RT, 1 h, 2.) reflux, 3 h 5: 62 percent / 1,2-dichloro-benzene / 8 h / Heating 6: 41 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / benzene / 4 h / Heating 7: 93 percent / 28percent NH4OH / methanol / 48 h / 150 °C 8: 80 percent / sodium bis(2-methoxyethoxy)aluminium hydride / toluene / 0.5 h / Heating View Scheme

1: 98 percent / NBS / CCl4 / 1 h 2: 1.) n-BuLi / 1.) Et2O, hexane, -78 deg C, 1 h, 2.) Et2O, hexane, RT, 12 h 3: 46 percent / Et3N, PPh3, CCl4 / acetonitrile / 1.) RT, 1 h, 2.) reflux, 3 h 4: 62 percent / 1,2-dichloro-benzene / 8 h / Heating 5: 41 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / benzene / 4 h / Heating 6: 93 percent / 28percent NH4OH / methanol / 48 h / 150 °C 7: 80 percent / sodium bis(2-methoxyethoxy)aluminium hydride / toluene / 0.5 h / Heating View Scheme

1: 1.) n-BuLi / 1.) Et2O, hexane, -78 deg C, 1 h, 2.) Et2O, hexane, RT, 12 h 2: 46 percent / Et3N, PPh3, CCl4 / acetonitrile / 1.) RT, 1 h, 2.) reflux, 3 h 3: 62 percent / 1,2-dichloro-benzene / 8 h / Heating 4: 41 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / benzene / 4 h / Heating 5: 93 percent / 28percent NH4OH / methanol / 48 h / 150 °C 6: 80 percent / sodium bis(2-methoxyethoxy)aluminium hydride / toluene / 0.5 h / Heating View Scheme