N-苄基-3-(羟基甲基)氮杂环丁烷合成路线 （共 5 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 16 h; 2: With sodium hydroxide; water in tetrahydrofuran 0.5 h;
参考文献
INDUSTRIAL RESEARCH LIMITED; ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
Patent: WO2008/79028 A1, 2008 ;
Location in patent: Page/Page column 15-17 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 16 h;
参考文献
Evans, Gary B.; Furneaux, Richard H.; Greatrex, Ben; Murkin, Andrew S.; Schramm, Vern L.; Tyler, Peter C.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 4 p. 948 - 956
反应条件
hydrogen; palladium(II) hydroxide/carbon in methanol 24 h;
参考文献
INDUSTRIAL RESEARCH LIMITED; ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
Patent: WO2008/79028 A1, 2008 ;
Location in patent: Page/Page column 15; 17 ;
反应条件
sodium hydroxide; bromine; nickel dichloride in 1,4-dioxane; water
参考文献
Shell Oil Company
Patent: US4778577 A1, 1988 ;
反应条件
hydrogen; palladium dihydroxide in methanol 24 h;
参考文献
Evans, Gary B.; Furneaux, Richard H.; Greatrex, Ben; Murkin, Andrew S.; Schramm, Vern L.; Tyler, Peter C.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 4 p. 948 - 956
