反应条件
1: SOCl2 / 1 h / 60 °C 2: CH2Cl2 / 1 h / 40 °C 3: 1.) NaNH2 / 1.) toluene, RT, 10 min, 2.) toluene, RT, 40 min 4: H2O, ethan. KOH / ethanol / 24 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 11 p. 1704 - 1711