N,N',N''-(次氮三-2,1-乙二基)三(3-羟基-2-氧代-1(2H)-吡啶乙酰胺合成路线 （共 8 条）
反应条件
hydrogen; acetic acid; palladium on activated charcoal in ethanol; water
18 h;
参考文献
Rai, Bijaya L.; Khodr, Hicham; Hider, Robert C.
Tetrahedron, 1999 , vol. 55, # 4 p. 1129 - 1142
反应条件
1: 1.) N-methylmorpholine, 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate / 1.) DMF, room temperature, 20 min, 2.) DMF, room temperature, 18 h
2: 65 percent / hydrogen, glacial acetic acid / Pd on carbon / ethanol; H2O / 18 h
View Scheme
参考文献
Rai, Bijaya L.; Khodr, Hicham; Hider, Robert C.
Tetrahedron, 1999 , vol. 55, # 4 p. 1129 - 1142
反应条件
1: 83 percent / aq. NaOH / 0.33 h
2: dicyclohexylcarbodiimide / tetrahydrofuran / 0 deg C, 20 min; room temperature, 1 h
3: 33 percent / Et3N / tetrahydrofuran / 1 h / Ambient temperature
View Scheme
参考文献
Fox, Raymond C.; Taylor, Paul D.
Synthetic Communications, 1998 , vol. 28, # 9 p. 1563 - 1574
反应条件
1: 77 percent / 24 h / Heating
2: 83 percent / aq. sodium hydroxide / methanol; H2O / 6 h / Heating
3: 82 percent / dicyclohexylcarboiimide / dimethylformamide
4: dimethylformamide / 0.5 h
5: H2, glacial acetic acid / Pd/C / ethanol
View Scheme
参考文献
Streater; Taylor; Hider; Porter
Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1749 - 1755
反应条件
1: dimethylformamide / 0.5 h
2: H2, glacial acetic acid / Pd/C / ethanol
View Scheme
参考文献
Streater; Taylor; Hider; Porter
Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1749 - 1755
反应条件
1: 1.) N-methylmorpholine, 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate / 1.) DMF, room temperature, 20 min, 2.) DMF, room temperature, 18 h
2: 65 percent / hydrogen, glacial acetic acid / Pd on carbon / ethanol; H2O / 18 h
View Scheme
参考文献
Rai, Bijaya L.; Khodr, Hicham; Hider, Robert C.
Tetrahedron, 1999 , vol. 55, # 4 p. 1129 - 1142
反应条件
triethylamine in tetrahydrofuran
1 h; Ambient temperature;
参考文献
Fox, Raymond C.; Taylor, Paul D.
Synthetic Communications, 1998 , vol. 28, # 9 p. 1563 - 1574
反应条件
1: dicyclohexylcarbodiimide / tetrahydrofuran / 0 deg C, 20 min; room temperature, 1 h
2: 33 percent / Et3N / tetrahydrofuran / 1 h / Ambient temperature
View Scheme
参考文献
Fox, Raymond C.; Taylor, Paul D.
Synthetic Communications, 1998 , vol. 28, # 9 p. 1563 - 1574
