6-氟-2-(环氧乙烷-2H)-3H,4H-苯并吡喃合成路线 （共 15 条）
反应条件
1: ethanol; sodium tetrahydroborate / 2 h / 0 °C / Inert atmosphere 2: sodium hydroxide / isopropyl alcohol; water / 1.5 h / 0 °C / Inert atmosphere View Scheme
反应条件
1: cyclohexane; 1,1-dimethylpropan-1-ol / 10 h / 20 °C 2: ethanol / Reflux 3: hydrogen / palladium hydroxide on carbon / ethyl acetate; ethanol / Inert atmosphere View Scheme
参考文献
MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A.; BARTOLI, Sandra; CIPOLLONE, Amalia; FATTORI, Daniela
Patent: WO2011/98474 A1, 2011 ;
反应条件
in 1,1-dimethylpropan-1-ol T=20°C; 12 h;
参考文献
Menarini International Operations Luxembourg S.A.; CIPOLLONE, Amalia; D'ANDREA, Piero; FATTORI, Daniela
Patent: WO2013/18053 A1, 2013 ;
Location in patent: Page/Page column 23; 24 ;
反应条件
1: isopropyl alcohol / Reflux 2: ammonium formate / palladium 10 on activated carbon / methanol / 3 h / Reflux View Scheme
参考文献
Haldar, Pranab; Golla, China Malakondaiah; Swapna, Akula; Kumar, Karri Vijaya; Jawlekar, Suhas; Tummala, Arjun Kumar; Patro, Deepali; Yarraguntla, Sesha Reddy; Ramakrishnan, Srividya; Chimala, Venkata Ramana Reddy
Patent: US2011/250454 A1, 2011 ;
反应条件
1: isopropyl alcohol / Reflux
2: ammonium formate / palladium 10 on activated carbon / methanol / 3 h / Reflux
3: hydrogenchloride / methanol / 25 - 35 °C
View Scheme
参考文献
Haldar, Pranab; Golla, China Malakondaiah; Swapna, Akula; Kumar, Karri Vijaya; Jawlekar, Suhas; Tummala, Arjun Kumar; Patro, Deepali; Yarraguntla, Sesha Reddy; Ramakrishnan, Srividya; Chimala, Venkata Ramana Reddy
Patent: US2011/250454 A1, 2011 ;
