1: 3-pyrrol-1-yl-propionic acid 4-iodo-benzyl ester in acetonitrile Electrochemical reaction; 2: anhydrous 1-octyne With copper(l) iodide; triethylamine; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=20°C; Sonogashira reaction; 12 h; 3: With sodium methylate in tetrahydrofuran; methanol T=20°C; 1 h;

1: With gallium(III) chloride in dichloromethane T=-78°C; chelation; 0.5 h; 2: With tri-n-butyl-tin hydride T=-78°C; Reduction; 1 h; Further stages.;

sodium borohydride in ethanol

hydrogenchloride in tetrahydrofuran; water; ethyl acetate

copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine T=50°C; Sonogashira Cross-Coupling; 12 h; Inert atmosphere;