(1R,2R)-(2-羟基-1-羟基甲基-丙基)-氨基甲酸叔丁酯合成路线 （共 5 条）
反应条件
sodium tetrahydroborate in ethanol
T=0 - 23°C; 3 h;
参考文献
Osman, Sami; Albert, Brian J.; Wang, Yanping; Li, Miaosheng; Czaicki, Nancy L.; Koide, Kazunori
Chemistry - A European Journal, 2011 , vol. 17, # 3 p. 895 - 904
反应条件
sodium tetrahydroborate; 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide
1.) THF, a) 0 deg C, 1 h, b) RT, 5 h, 2.) THF, EtOH, 0 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Nakamura; Hirai; Tamotsu; Yonezawa; Shin
Bulletin of the Chemical Society of Japan, 1995 , vol. 68, # 5 p. 1369 - 1377
反应条件
in 1,4-dioxane; tert-butyl alcohol
Ambient temperature;
参考文献
Neugebauer; Escher
Helvetica Chimica Acta, 1989 , vol. 72, # 6 p. 1319 - 1323
反应条件
1: 49.0 g / Et3N / dioxane; H2O / 21 h / Ambient temperature
2: NaBH4 / ethanol / 1) 5 deg C, 15 min. 2) room temp. 70 min.
View Scheme
参考文献
Saito, Kunio; Saijo, Shigeyoshi; Kotera, Keishi; Date, Tadamasa
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 4 p. 1342 - 1350
反应条件
sodium tetrahydroborate; dicyclohexyl-carbodiimide
1) THF, 0 deg C / 1 h -> r.t. / 5 h 2) 30 min; Yield given. Multistep reaction;
参考文献
Nakamura, Yutaka; Shin, Chung-gi
Chemistry Letters, 1992 , # 1 p. 49 - 52
