反应条件
1: 95.5 percent / pyridine / CH2Cl2 / Ambient temperature
2: 55.6 percent / BF3*Et2O / CH2Cl2 / 1.) -78 deg C, 1 h, 2.) RT, overnight
3: 100 percent / H2, triethylamine / 10percent Pd/C / 12 h / Ambient temperature
4: 71 percent / NaHCO3 / CHCl3 / 0.33 h
View Scheme
参考文献
Costa, Brian R., de; Lewin, Anita H.; Rice, Kenner C.; Skolnick, Phil; Schoenheimer, Joyce A.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1531 - 1538
