(S)-1-氰基-2-苯基乙基氨基甲酸叔丁酯合成路线 （共 9 条）
反应条件
triethylamine; trifluoroacetic anhydride in tetrahydrofuran 0.5 h; Ambient temperature;
参考文献
Thompson, Stewart A.; Andrews, Peter R.; Hanzlik, Robert P.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 1 p. 104 - 111
反应条件
1: With 3 A molecular sieve; hydroxylamine hydrochloride; 1,8-diazabicyclo[5.4.0]undec-7-ene in dichloromethane T=20°C; 10 h; 2: in dichloromethane T=20°C; 5 h; Further stages.;
参考文献
Zhu, Jia-Liang; Lee, Fa-Yen; Wu, Jen-Dar; Kuo, Chun-Wei; Shia, Kak-Shan
Synlett, 2007 , # 8 p. 1317 - 1319
反应条件
N-(o-trifluoromethylbenzyl)quininium bromide; potassium carbonate in toluene T=-20°C; 42 h; Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 71, # 26 p. 9869 - 9872
反应条件
1: NH3 / tetrahydrofuran / 1.5 h / 0 °C 2: TEA; (CF3CO)2O / tetrahydrofuran / 0.5 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 1 p. 72 - 79
反应条件
1: TEA / tetrahydrofuran / 0.5 h / -10 °C 2: NH3 / tetrahydrofuran / 1.5 h / 0 °C 3: TEA; (CF3CO)2O / tetrahydrofuran / 0.5 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 1 p. 72 - 79
反应条件
1: aq. NaOH / dioxane / 0 °C 2: ethyl chloroformate; triethylamine; ammonia(g) / CH2Cl2 / -10 °C 3: cyanuric chloride / dimethylformamide / 0.5 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 48, # 8 p. 1465 - 1468
反应条件
1: aq. NaOH / dioxane / 0 °C 2: ethyl chloroformate; triethylamine; ammonia(g) / CH2Cl2 / -10 °C 3: cyanuric chloride / dimethylformamide / 0.5 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 48, # 8 p. 1465 - 1468
反应条件
ammonia; hydrogen; nickel in ethanol; water Hydrogenation; P=2250.18 Torr; 4 h;
参考文献
Hemantha, Hosahalli P.; Sureshbabu, Vommina V.
Tetrahedron Letters, 2009 , vol. 50, # 50 p. 7062 - 7066
Title/Abstract Full Text View citing articles Show Details
Sureshbabu, Vommina V.; Chennakrishnareddy, Gundala; Hemantha, Hosahalli P.
Synlett, 2010 , # 5 p. 715 - 720
反应条件
trifluoroacetic acid in dichloromethane
T=-15°C; 5 h;
参考文献
McLaughlin, Mark; Mohareb, Rafat M.; Rapoport, Henry
Journal of Organic Chemistry, 2003 , vol. 68, # 1 p. 50 - 54
