2-羧基甲基氨基-4-氯苯甲酸合成路线 （共 11 条）
反应条件
hydrogenchloride; potassium hydroxide; potassium carbonate in water
参考文献
Fuji Chemical Industry Co., Ltd.; Fujisawa Pharmaceutical Co., Ltd.
Patent: US6201121 B1, 2001 ;
反应条件
copper; potassium carbonate in N,N-dimethyl-formamide
T=25°C; Ullmann condensation; 0.416667 h; ultrasonic irradiation;
参考文献
Docampo, Maite L.; Pellon, Rolando F.; Estevez-Braun, Ana; Ravelo, Angel G.
European Journal of Organic Chemistry, 2007 , # 24 p. 4111 - 4115
反应条件
sodium hydroxide in water
T=60°C; 48 h;
参考文献
NYCOMED GMBH; BARTELS, Bjoern; WEINBRENNER, Steffen; MARX, Degenhard; DIEFENBACH, Joerg; DUNKERN, Torsten; MENGE, Wiro M.P.B.; CHRISTIAANS, Johannes A. M.
Patent: WO2010/15589 A1, 2010 ;
Location in patent: Page/Page column 107 ;
WO 2010/015589 A1
反应条件
potassium hydroxide; potassium carbonate in water
参考文献
Hoechst Aktiengesellschaft
Patent: US5821385 A1, 1998 ;
反应条件
1: aqueous NaOH; aqueous H2O2
View Scheme
参考文献
Sadler; Warren
Journal of the American Chemical Society, 1956 , vol. 78, p. 1251,1254
参考文献
Holt; Sadler
Proceedings of the Royal Society of London, Series B: Biological Sciences, 1958 , vol. 148, p. 481,488
Full Text Show Details
Sadler; Warren
Journal of the American Chemical Society, 1956 , vol. 78, p. 1251,1254
反应条件
sodium hydroxide in water
参考文献
Nirogia, Ramakrishna V.S.; Kambhampati, Ramasastri; Daulatabad, Anand V.; Gudla, Parandhama; Shaikh, Mohammad; Achanta, Pramod Kumar; Shinde, Anil K.; Dubey, Pramod Kumar
Journal of Enzyme Inhibition and Medicinal Chemistry, 2011 , vol. 26, # 3 p. 341 - 349
参考文献
Heller; Hessel
Journal fuer Praktische Chemie (Leipzig), 1929 , vol. <2> 120, p. 69
反应条件
1: glacial acetic acid / Erwaermen auf 80grad
2: KOH-solution
View Scheme
参考文献
Heller; Hessel
Journal fuer Praktische Chemie (Leipzig), 1929 , vol. <2> 120, p. 69
反应条件
sodium acetate
1 h; Heating;
参考文献
Rodriguez-Dominguez, Juan C.; Balbuzano-Deus, Alexander; Lopez-Lopez, Miguel A.; Kirsch, Gilbert
Journal of Heterocyclic Chemistry, 2007 , vol. 44, # 1 p. 273 - 275
