4-(3-氯苯基l)-哌啶合成路线 (共 3 条)
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 3 h; Ambient temperature;
参考文献
Ferrand, Gerard; Dumas, Herve; Depin, Jean-Claude; Chavernac, Gilles
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 337 - 346
反应条件
1: 61 percent / NH3 (34 percent) / H2O / 0.5 h / 190 °C 2: 81 percent / LiAlH4 / tetrahydrofuran / 3 h / Ambient temperature View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 22, p. 337 - 346
反应条件
trifluorormethanesulfonic acid T=25°C;
参考文献
Tetrahedron Letters, , vol. 42, # 34 p. 5821 - 5823