1-(4-溴丁基)-4-硝基苯合成路线 （共 4 条）
反应条件
carbon tetrabromide; triphenylphosphine in acetonitrile
T=20°C; 1 h;
参考文献
Zou; Kopajtic; Katz; Wirtz; Justice Jr.; Newman
Journal of Medicinal Chemistry, 2001 , vol. 44, # 25 p. 4453 - 4461
反应条件
triphenylphosphine in tetrahydrofuran
参考文献
SmithKline Beecham Corporation
Patent: US2002/147334 A1, 2002 ;
反应条件
pyridine in acetonitrile
参考文献
Bristol-Myers Squibb Pharma Company
Patent: EP892780 B1, 2002 ;
反应条件
1: 98 percent / BH3*SMe2 / tetrahydrofuran / 1 h
2: 94 percent / triphenylphosphine; carbon tetrabromide / acetonitrile / 1 h / 20 °C
View Scheme
参考文献
Zou; Kopajtic; Katz; Wirtz; Justice Jr.; Newman
Journal of Medicinal Chemistry, 2001 , vol. 44, # 25 p. 4453 - 4461
