N-(4-氨基苄基)-乙酰胺合成路线 （共 11 条）
反应条件
sodium hydroxide 2.5 h; Heating;
参考文献
King; Rathore; Lam; Guo; Klassen
Journal of the American Chemical Society, 1992 , vol. 114, # 8 p. 3028 - 3033
反应条件
hydrogen; Raney Ni in tetrahydrofuran
T=20°C; P=760.051 Torr; 16 h;
参考文献
PHARMACOPEIA, INC.
Patent: WO2007/104053 A2, 2007 ;
Location in patent: Page/Page column 45 ;
WO 2007/104053 A2
参考文献
King, James F.; Guo, Zhen Rong; Klassen, Darryl F.
Journal of Organic Chemistry, 1994 , vol. 59, # 5 p. 1095 - 1101
反应条件
lanthanum trifluoromethanesulphonate
T=50°C; 24 h; Inert atmosphere; chemoselective reaction;
参考文献
Morimoto, Hiroyuki; Fujiwara, Risa; Shimizu, Yuhei; Morisaki, Kazuhiro; Ohshima, Takashi
Organic Letters, 2014 , vol. 16, # 7 p. 2018 - 2021
反应条件
in tetrahydrofuran
T=20°C; 0.416667 h;
参考文献
Chung, In Hwa; Cha, Ki Suk; Seo, Jae Hong; Kim, Joong Hyup; Chung, Bong Young; Kim, Choong Sup
Heterocycles, 2000 , vol. 53, # 3 p. 529 - 533
反应条件
1: 54 percent / HNO3, H2SO4 / 10 - 15 °C
2: 80 percent / Sn, HCl / 0.33 h / 90 °C
View Scheme
参考文献
King; Rathore; Lam; Guo; Klassen
Journal of the American Chemical Society, 1992 , vol. 114, # 8 p. 3028 - 3033
反应条件
2: Fe; NH4Cl
View Scheme
参考文献
Katsura; Tomishi; Inoue; Sakane; Matsumoto; Morinaga; Ishikawa; Takasugi
Journal of Medicinal Chemistry, 2000 , vol. 43, # 17 p. 3315 - 3321
反应条件
1: N2H4*H2O
3: Fe; NH4Cl
View Scheme
参考文献
Katsura; Tomishi; Inoue; Sakane; Matsumoto; Morinaga; Ishikawa; Takasugi
Journal of Medicinal Chemistry, 2000 , vol. 43, # 17 p. 3315 - 3321
反应条件
2: N2H4*H2O
4: Fe; NH4Cl
View Scheme
参考文献
Katsura; Tomishi; Inoue; Sakane; Matsumoto; Morinaga; Ishikawa; Takasugi
Journal of Medicinal Chemistry, 2000 , vol. 43, # 17 p. 3315 - 3321
反应条件
in water
T=25°C; pH - yield profile; role of the general base assisted hydrolysis; Rate constant;
参考文献
King, James F.; Guo, Zhen Rong; Klassen, Darryl F.
Journal of Organic Chemistry, 1994 , vol. 59, # 5 p. 1095 - 1101
