5-羟基苯并呋喃-2-羧酸乙酯合成路线 （共 7 条）
反应条件
ethanethiol; aluminium trichloride
参考文献
SmithKline Beecham Corporation
Patent: US6518267 B1, 2003 ;
US 6518267 B1
参考文献
Fisons plc
Patent: US4670452 A1, 1987 ;
反应条件
palladium on activated charcoal; hydrogen in ethanol
T=20°C;
参考文献
THE UNIVERSITY OF NOTTINGHAM; MISTRY, Shailesh; DARAS, Etienne; FROMONT, Christophe; JADHAV, Gopal; FISCHER, Peter Martin; KELLAM, Barrie; HILL, Stephen John; BAKER, Jillian Glenda
Patent: WO2013/121209 A1, 2013 ;
Location in patent: Page/Page column 18 ;
反应条件
1: 33 percent / K2CO3 / dimethylformamide / 80 °C
2: 39 percent / BBr3 / CH2Cl2 / 20 °C
View Scheme
参考文献
Haning, Helmut; Mueller, Ulrich; Schmidt, Gunter; Schmeck, Carsten; Voehringer, Verena; Kretschmer, Axel; Bischoff, Hilmar
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 14 p. 3992 - 3996
反应条件
1: potassium carbonate / acetonitrile / |Reflux
2: MgBr2(Et2O) / benzene; diethyl ether / |Inert atmosphere; |Reflux
3: potassium carbonate / acetonitrile / 60 h / |Reflux
4: hydrogen; palladium on activated charcoal / ethanol / 20 °C
View Scheme
参考文献
THE UNIVERSITY OF NOTTINGHAM; MISTRY, Shailesh; DARAS, Etienne; FROMONT, Christophe; JADHAV, Gopal; FISCHER, Peter Martin; KELLAM, Barrie; HILL, Stephen John; BAKER, Jillian Glenda
Patent: WO2013/121209 A1, 2013 ;
反应条件
1: MgBr2(Et2O) / benzene; diethyl ether / |Inert atmosphere; |Reflux
2: potassium carbonate / acetonitrile / 60 h / |Reflux
3: hydrogen; palladium on activated charcoal / ethanol / 20 °C
View Scheme
参考文献
THE UNIVERSITY OF NOTTINGHAM; MISTRY, Shailesh; DARAS, Etienne; FROMONT, Christophe; JADHAV, Gopal; FISCHER, Peter Martin; KELLAM, Barrie; HILL, Stephen John; BAKER, Jillian Glenda
Patent: WO2013/121209 A1, 2013 ;
反应条件
1: potassium carbonate / acetonitrile / 60 h / |Reflux
2: hydrogen; palladium on activated charcoal / ethanol / 20 °C
View Scheme
参考文献
THE UNIVERSITY OF NOTTINGHAM; MISTRY, Shailesh; DARAS, Etienne; FROMONT, Christophe; JADHAV, Gopal; FISCHER, Peter Martin; KELLAM, Barrie; HILL, Stephen John; BAKER, Jillian Glenda
Patent: WO2013/121209 A1, 2013 ;
