(E)-5-(2-羧基乙烯基)脲啶合成路线 （共 5 条）
反应条件
1: 42 percent / triethylamine / dimethylformamide; H2O / 20 h / 100 °C 2: 65 percent / I2, KIO3, 5 N H2SO4 / H2O; acetonitrile / 0.5 h / 55 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 2 p. 717 - 723
反应条件
1: 42 percent / triethylamine / dimethylformamide; H2O / 20 h / 100 °C 2: 65 percent / I2, KIO3, 5 N H2SO4 / H2O; acetonitrile / 0.5 h / 55 °C 3: 81 percent / 5 N H2SO4 / 36 h / 25 °C View Scheme
参考文献
Kumar, Rakesh; Xu, Lihua; Knaus, Edward E.; Wiebe, Leonard I.; Tovell, Dorothy R.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 717 - 723
反应条件
potassium hydroxide
T=25°C; 2 h;
参考文献
Kumar, Rakesh; Xu, Lihua; Knaus, Edward E.; Wiebe, Leonard I.; Tovell, Dorothy R.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 717 - 723
反应条件
sodium hydroxide
Ambient temperature;
参考文献
Clercq, Erik De; Desgranges, Claude; Herdewijn, Piet; Sim, Iain S.; Jones, A. Stanley; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 2 p. 213 - 217
反应条件
1: 86 percent / Pd(OAc)2, Ph3P, TEA / 1 h / Heating
2: 67 percent / aq. 1 N NaOH / Ambient temperature
View Scheme
参考文献
Clercq, Erik De; Desgranges, Claude; Herdewijn, Piet; Sim, Iain S.; Jones, A. Stanley; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 2 p. 213 - 217
