(S)-4-苯基-2-恶唑烷酮合成路线 （共 54 条）
反应条件
sodium ethanolate in ethanol 15 h; Heating;
参考文献
Tian, Xiang-Yin; Han, Jian-Wei; Zhao, Qiong; Wong, Henry N. C.
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 22 p. 3686 - 3700
反应条件
1: With 1,8-diazabicyclo[5.4.0]undec-7-ene in N,N-dimethyl-formamide T=20°C; Michael addition; 0.333333 h; 2: With hydrogenchloride in methanol T=70°C; Hydrolysis; 3: With cation-exchange resin Dowex; water Cyclization; ring cleavage; hydrolysis;
参考文献
Soloshonok; Cai; Hruby
Organic letters, 2000 , vol. 2, # 6 p. 747 - 750
反应条件
1: With 1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile T=20°C; 0.75 h; 2: With tributylphosphine; di-tert-butylazodicarboxylate in acetonitrile T=0°C; Mitsunobu reaction; 0.333333 h;
参考文献
Dinsmore, Christopher J.; Mercer, Swati P.
Organic Letters, 2004 , vol. 6, # 17 p. 2885 - 2888
反应条件
1: With 1,8-diazabicyclo[5.4.0]undec-7-ene in N,N-dimethyl-formamide T=20°C; Michael addition; 2: With hydrogenchloride in methanol; water T=70°C; Hydrolysis; 3: With cation-exchange resin Dowex; water Cyclization; ring cleavage; hydrolysis;
参考文献
Soloshonok; Cai; Hruby
Organic letters, 2000 , vol. 2, # 6 p. 747 - 750
反应条件
N,O-bis-(trimethylsilyl)-acetamide; tetrabutyl ammonium fluoride in toluene T=45 - 50°C; 2 h;
参考文献
WO2006/137080 A1, ;
Page/Page column 12 ;
反应条件
tetrabutyl ammonium fluoride in acetonitrile T=20 - 25°C; 2.5 - 3 h;
参考文献
WO2007/72088 A1, ;
Page/Page column 19 ;
反应条件
carbon in tetrahydrofuran T=50°C; 48 h;
参考文献
Alouane, Nacira; Boutier, Audrey; Baron, Cyriella; Vrancken, Emmanuel; Mangeney, Pierre
Synthesis, 2006 , # 5 p. 885 - 889
反应条件
1: in acetonitrile T=20°C; Acylation; 2 h; 2: With p-toluenesulfonyl chloride in acetonitrile T=25°C; Cyclization; 10 h;
参考文献
Feroci, Marta; Inesi, Achille; Mucciante, Vittoria; Rossi, Leucio
Tetrahedron Letters, 1999 , vol. 40, # 33 p. 6059 - 6060
反应条件
(R)-BTM; sodium sulfate; N-ethyl-N,N-diisopropylamine in chloroform T=20°C; 8.5 h;
参考文献
Journal of the American Chemical Society, , vol. 128, # 20 p. 6536 - 6537
反应条件
lithium hydroxide hydrate; water; dihydrogen peroxide in tetrahydrofuran T=20°C; Inert atmosphere;
参考文献
Coulbeck, Elliot; Dingjan, Marco; Eames, Jason
Chirality, 2010 , vol. 22, # 2 p. 193 - 205
