1: With 4-(N,N-dimethlyamino)pyridine; triethylamine in tetrahydrofuran T=25°C; Inert atmosphere; 2: With lithium bromide in tetrahydrofuran T=20 - 70°C; Inert atmosphere;
1: 5-hydroxypentyne With n-butyllithium in tetrahydrofuran; toluene T=-68°C; 1 h; 2: triethylsilyl chloride in tetrahydrofuran; toluene T=-68 - 20°C; 20 h; 3: With hydrogenchloride in tetrahydrofuran; toluene T=20°C; 48 h;
参考文献
Wennekes, Tom; Van Den Berg, Richard J. B. H. N.; Donker, Wilma; Van Der Marel, Gijsbert A.; Strijland, Anneke; Aerts, Johannes M. F. G.; Overkleeft, Herman S.
Journal of Organic Chemistry, 2007 , vol. 72, # 4 p. 1088 - 1097
