4,6-二氯噻吩并[2,3-b]吡啶合成路线 （共 13 条）
反应条件
acetic acid; zinc 1 h; Heating;
参考文献
Barker, John M.; Huddleston, Patrick R.; Holmes, David
Journal of Chemical Research, Miniprint, 1985 , # 7 p. 2501 - 2523
反应条件
dichlorophenyl phosphine oxide
T=160 - 170°C; 1 h;
参考文献
Barker, John M.; Huddleston, Patrick R.; Holmes, David
Journal of Chemical Research, Miniprint, 1985 , # 7 p. 2501 - 2523
反应条件
1: 93 percent / 2M aq. NaOH / 2 h / Heating
2: 38 percent / PhPOCl2 / 1 h / 160 - 170 °C
View Scheme
参考文献
Barker, John M.; Huddleston, Patrick R.; Holmes, David
Journal of Chemical Research, Miniprint, 1985 , # 7 p. 2501 - 2523
反应条件
1: 0.6 g / Br2 / acetic acid / Heating
2: 32 percent / PhPOCl2 / 0.75 h / 160 - 170 °C
3: 1.) 1.55M BuLi/hexane, 2.) MeI / 1.) ether, THF, -70 deg C, 15 min, 2.) r.t., 2 h
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参考文献
Barker, John M.; Huddleston, Patrick R.; Holmes, David
Journal of Chemical Research, Miniprint, 1986 , # 4 p. 1063 - 1100
反应条件
1: 72 percent / toluene / 3 h / Heating
2: 66 percent / diphenyl ether / 0.17 h / Heating
3: 38 percent / PhPOCl2 / 1 h / 160 - 170 °C
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参考文献
Barker, John M.; Huddleston, Patrick R.; Holmes, David
Journal of Chemical Research, Miniprint, 1985 , # 7 p. 2501 - 2523
反应条件
1: 73 percent / NaH / tetrahydrofuran / 3 h / Heating
2: 93 percent / 2M aq. NaOH / 2 h / Heating
3: 38 percent / PhPOCl2 / 1 h / 160 - 170 °C
View Scheme
参考文献
Barker, John M.; Huddleston, Patrick R.; Holmes, David
Journal of Chemical Research, Miniprint, 1985 , # 7 p. 2501 - 2523
反应条件
1: 66 percent / diphenyl ether / 0.17 h / Heating
2: 38 percent / PhPOCl2 / 1 h / 160 - 170 °C
View Scheme
参考文献
Barker, John M.; Huddleston, Patrick R.; Holmes, David
Journal of Chemical Research, Miniprint, 1985 , # 7 p. 2501 - 2523
反应条件
1: 32 percent / PhPOCl2 / 0.75 h / 160 - 170 °C
2: 1.) 1.55M BuLi/hexane, 2.) MeI / 1.) ether, THF, -70 deg C, 15 min, 2.) r.t., 2 h
View Scheme
参考文献
Barker, John M.; Huddleston, Patrick R.; Holmes, David
Journal of Chemical Research, Miniprint, 1986 , # 4 p. 1063 - 1100
反应条件
1: 59 percent / 2M NaOH / 4 h / Heating
2: 32 percent / PhPOCl2 / 0.75 h / 160 - 170 °C
3: 1.) 1.55M BuLi/hexane, 2.) MeI / 1.) ether, THF, -70 deg C, 15 min, 2.) r.t., 2 h
View Scheme
参考文献
Barker, John M.; Huddleston, Patrick R.; Holmes, David
Journal of Chemical Research, Miniprint, 1986 , # 4 p. 1063 - 1100
反应条件
n-butyllithium; hexane; methyl iodide
1.) ether, THF, -70 deg C, 15 min, 2.) r.t., 2 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Barker, John M.; Huddleston, Patrick R.; Holmes, David
Journal of Chemical Research, Miniprint, 1986 , # 4 p. 1063 - 1100
