6-氯-4-甲氧基-噻吩并[2,3-b]吡啶合成路线 （共 6 条）
反应条件
in methanol
6 h; Heating;
参考文献
Barker, John M.; Huddleston, Patrick R.; Holmes, David
Journal of Chemical Research, Miniprint, 1985 , # 7 p. 2501 - 2523
反应条件
1: 72 percent / toluene / 3 h / Heating
2: 66 percent / diphenyl ether / 0.17 h / Heating
3: 38 percent / PhPOCl2 / 1 h / 160 - 170 °C
4: 71 percent / methanol / 6 h / Heating
View Scheme
参考文献
Barker, John M.; Huddleston, Patrick R.; Holmes, David
Journal of Chemical Research, Miniprint, 1985 , # 7 p. 2501 - 2523
反应条件
1: 38 percent / PhPOCl2 / 1 h / 160 - 170 °C
2: 71 percent / methanol / 6 h / Heating
View Scheme
参考文献
Barker, John M.; Huddleston, Patrick R.; Holmes, David
Journal of Chemical Research, Miniprint, 1985 , # 7 p. 2501 - 2523
反应条件
1: 93 percent / 2M aq. NaOH / 2 h / Heating
2: 38 percent / PhPOCl2 / 1 h / 160 - 170 °C
3: 71 percent / methanol / 6 h / Heating
View Scheme
参考文献
Barker, John M.; Huddleston, Patrick R.; Holmes, David
Journal of Chemical Research, Miniprint, 1985 , # 7 p. 2501 - 2523
反应条件
1: 73 percent / NaH / tetrahydrofuran / 3 h / Heating
2: 93 percent / 2M aq. NaOH / 2 h / Heating
3: 38 percent / PhPOCl2 / 1 h / 160 - 170 °C
4: 71 percent / methanol / 6 h / Heating
View Scheme
参考文献
Barker, John M.; Huddleston, Patrick R.; Holmes, David
Journal of Chemical Research, Miniprint, 1985 , # 7 p. 2501 - 2523
反应条件
1: 66 percent / diphenyl ether / 0.17 h / Heating
2: 38 percent / PhPOCl2 / 1 h / 160 - 170 °C
3: 71 percent / methanol / 6 h / Heating
View Scheme
参考文献
Barker, John M.; Huddleston, Patrick R.; Holmes, David
Journal of Chemical Research, Miniprint, 1985 , # 7 p. 2501 - 2523
