1-甲基-6-硝基-1H-吲哚合成路线 （共 9 条）
反应条件
nickel; hydrazine hydrate in methanol Ambient temperature;
参考文献
Coullet, Fabien; Morel, Sandrine; Boyer, Gerard; Galy, Jean Pierre
Synthetic Communications, 1998 , vol. 28, # 1 p. 147 - 157
反应条件
1: 6-nitro-1H-indole With sodium hydride in N,N-dimethyl-formamide
0.166667 h;
2: methyl iodide in N,N-dimethyl-formamide
T=20°C;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: WO2009/16119 A1, 2009 ;
Location in patent: Page/Page column 65 ;
WO 2009/016119 A1
反应条件
CH3I; NaH in dimethylformamide [DMF]; water
参考文献
Hoffmann-La Roche Inc.
Patent: US6228877 B1, 2001 ;
反应条件
potassium carbonate in n-heptane; water; ethyl acetate; N,N-dimethyl-formamide
参考文献
Hoffmann-La Roche Inc.
Patent: US6326501 B1, 2001 ;
反应条件
1: 6-nitro-indoline With sodium hydride in N,N-dimethyl-formamide
T=20°C; 3 h;
2: methyl iodide in N,N-dimethyl-formamide
T=20°C; 16 h;
参考文献
Laconde, Guillaume; Carato, Pascal; Poupaert, Jacques H.; Berthelot, Pascal; Depreux, Patrick; Henichart, Jean-Pierre
Monatshefte fur Chemie, 2003 , vol. 134, # 7 p. 1037 - 1043
反应条件
NaH in dimethylformamide ('DMF')
参考文献
F.HOFFMANN-LA ROCHE AG
Patent: EP1064279 B1, 2003 ;
反应条件
nitric acid; acetic anhydride
T=-70°C; 3 h; Title compound not separated from byproducts;
参考文献
Pelkey; Gribble
Synthesis, 1999 , # 7 p. 1117 - 1122
参考文献
Terent'ew; Preobrashenskaja
Doklady Akademii Nauk SSSR, 1958 , vol. 118, p. 302,303
Doklady Chemistry, 118-123 <1958> 49, 50
反应条件
1: concentrated sulfuric acid; nitric acid / <3
2: tetrachloro-<1,4>benzoquinone; xylene
View Scheme
参考文献
Terent'ew; Preobrashenskaja
Doklady Akademii Nauk SSSR, 1958 , vol. 118, p. 302,303
Doklady Chemistry, 118-123 <1958> 49, 50
