7-溴喹啉-2(1H)-酮合成路线 （共 11 条）
反应条件
AlCl3, aluminium chloride in chlorobenzene T=90°C; 1 h;
参考文献
WO2006/134378 A1, ;
Page/Page column 61-62 ;
WO 2006/134378 A1
反应条件
hydrogenchloride; water in 1,4-dioxane 1 h; Heating / reflux;
参考文献
WO2008/71961 A1, ;
Page/Page column 103-104 ;
WO 2008/071961 A1
反应条件
AlCl3, aluminium chloride; chlorobenzene T=0 - 12°C;
参考文献
US2011/178041 A1, ;
Page/Page column 28 ;
反应条件
aluminium trichloride in chlorobenzene T=100°C; Cyclization;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 18 p. 2753 - 2758
反应条件
1: diethyl ether 2: 98percent H2SO4 / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 10 p. 2048 - 2056
反应条件
in ethylene glycol 15 h; Reflux;
参考文献
Synthesis, , # 13 p. 2039 - 2044
反应条件
sulfuric acid Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 10 p. 2048 - 2056
反应条件
trichlorophosphate T=65°C; 1 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/134378 A1, 2006 ;
Location in patent: Page/Page column 61-62 ;
WO 2006/134378 A1
反应条件
1: With thionyl chloride in dichloromethane; N,N-dimethyl-formamide 2 h; Heating / reflux; 2: in dichloromethane; water; N,N-dimethyl-formamide pH=> 7;
参考文献
SANOFI-AVENTIS U.S. LLC
Patent: WO2009/2955 A1, 2008 ;
Location in patent: Page/Page column 10 ;
反应条件
trichlorophosphate T=65°C; 1 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/134378 A1, 2006 ;
Location in patent: Page/Page column 61-62 ;
WO 2006/134378 A1
