4,5-二氯-2-(甲硫基)嘧啶合成路线 （共 2 条）
反应条件
1: With trichlorophosphate
2 h; Reflux;
2: With water; potassium carbonate
pH=7 - 8;
参考文献
PFIZER INC.; NAIR, Sajiv, Krishnan; PLANKEN, Simon, Paul
Patent: WO2012/52948 A1, 2012 ;
Location in patent: Page/Page column 53 ;
WO 2012/052948 A1
反应条件
1.1: acetic anhydride; acetic acid / 0.5 h / 80 °C
1.2: 24 h / 50 - 60 °C
2.1: trichlorophosphate / 2 h / Reflux
2.2: pH 7 - 8
View Scheme
参考文献
PFIZER INC.; NAIR, Sajiv, Krishnan; PLANKEN, Simon, Paul
Patent: WO2012/52948 A1, 2012 ;
WO 2012/052948 A1
