3-(2-二甲基氨基乙基)-1H-吲哚-5-胺合成路线 （共 6 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol
P=2280 Torr; 6 h;
参考文献
Macor; Post; Ryan
Synthetic Communications, 1993 , vol. 23, # 1 p. 65 - 72
反应条件
1: With tris-(dibenzylideneacetone)dipalladium(0) in tetrahydrofuran
T=20°C; 0.0833333 h;
2: With lithium hexamethyldisilazane in tetrahydrofuran
T=20°C; 21 h; Heating / reflux;
3: With hydrogenchloride; sodium hydroxide; water
more than 3 stages;
参考文献
Maddaford, Shawn; Ramnauth, Jailall; Rakhit, Suman; Patman, Joanne; Renton, Paul; Annedi, Subhash C.
Patent: US2006/258721 A1, 2006 ;
Location in patent: Page/Page column 43 ;
US 20060258721 A1
反应条件
1: phthalimide / diethyl ether / 72 h / Ambient temperature
2: diethyl ether / 1 h / Ambient temperature
3: 1.) borane, 2.) CsF, sodium carbonate / 1.) THF, RT, 16 h, 2.) EtOH, reflux, 16 h
4: 99 percent / H2 / 10percent Pd/C / ethanol / 6 h / 2280 Torr
View Scheme
参考文献
Macor; Post; Ryan
Synthetic Communications, 1993 , vol. 23, # 1 p. 65 - 72
反应条件
1: diethyl ether / 1 h / Ambient temperature
2: 1.) borane, 2.) CsF, sodium carbonate / 1.) THF, RT, 16 h, 2.) EtOH, reflux, 16 h
3: 99 percent / H2 / 10percent Pd/C / ethanol / 6 h / 2280 Torr
View Scheme
参考文献
Macor; Post; Ryan
Synthetic Communications, 1993 , vol. 23, # 1 p. 65 - 72
反应条件
1: 1.) borane, 2.) CsF, sodium carbonate / 1.) THF, RT, 16 h, 2.) EtOH, reflux, 16 h
2: 99 percent / H2 / 10percent Pd/C / ethanol / 6 h / 2280 Torr
View Scheme
参考文献
Macor; Post; Ryan
Synthetic Communications, 1993 , vol. 23, # 1 p. 65 - 72
反应条件
1: ethanol
2: Na2S2O4; aq.-ethanolic NaOH
View Scheme
参考文献
Shaw; Woolley
Journal of the American Chemical Society, 1953 , vol. 75, p. 1877,1880
