5-氨基-1-(3,5-二氯-4-(4-氯苯甲酰基)苄基)-1H-1,2,3-三氮唑-4-甲酰胺合成路线 （共 11 条）
反应条件
potassium carbonate in dimethyl sulfoxide 2 h; Ambient temperature;
参考文献
Cottrell, Ian F.; Hands, David; Houghton, Peter G.; Humphrey, Guy R.; Wright, Stanley H. B.
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 2 p. 301 - 304
反应条件
potassium carbonate in acetonitrile Heating;
参考文献
WO2011/28288 A1, ;
Page/Page column 18 ;
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -50 deg C, 1.5 h, 2.) Et2O, from -50 deg C to RT 2: SOCl2, DMF / 3 h / Heating 3: AlCl3 / CCl4 / 15 h / 85 °C 4: 51.4 percent / dibenzoyl peroxide, NBS / benzene / 24 h / Heating 5: 1.) NaH / 1.) DMF, RT, 20 min, 2.) DMF, RT, 1 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 9 p. 2843 - 2852
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -70 deg C, 30 min, 2.) THF, -70 deg C, 4 h 2: 51.4 percent / dibenzoyl peroxide, NBS / benzene / 24 h / Heating 3: 1.) NaH / 1.) DMF, RT, 20 min, 2.) DMF, RT, 1 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 9 p. 2843 - 2852
反应条件
1: SOCl2, DMF / 3 h / Heating 2: AlCl3 / CCl4 / 15 h / 85 °C 3: 51.4 percent / dibenzoyl peroxide, NBS / benzene / 24 h / Heating 4: 1.) NaH / 1.) DMF, RT, 20 min, 2.) DMF, RT, 1 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 9 p. 2843 - 2852
反应条件
1: AlCl3 / CCl4 / 15 h / 85 °C 2: 51.4 percent / dibenzoyl peroxide, NBS / benzene / 24 h / Heating 3: 1.) NaH / 1.) DMF, RT, 20 min, 2.) DMF, RT, 1 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 9 p. 2843 - 2852
反应条件
1: 51.4 percent / dibenzoyl peroxide, NBS / benzene / 24 h / Heating 2: 1.) NaH / 1.) DMF, RT, 20 min, 2.) DMF, RT, 1 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 9 p. 2843 - 2852
反应条件
1: NaN3 / ethanol / 5 h / Heating 2: 1.) NaOCH3 / 1.) EtOH, reflux, 20 min, 2.) EtOH, 60 deg C, 1 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 9 p. 2843 - 2852
反应条件
1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / Cooling 2: potassium carbonate / acetonitrile / Heating View Scheme
反应条件
1: 4-(N,N-dimethlyamino)pyridine; 1H-imidazole / Cooling 2: n-butyllithium / hexane; tetrahydrofuran / Cooling 3: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / Cooling 4: potassium carbonate / acetonitrile / Heating View Scheme
