1-(6-甲氧基-1-(苯基磺酰基)-1H-吲哚-3-基)乙酮合成路线 （共 9 条）
反应条件
potassium carbonate in methanol; water 2 h; Heating;
参考文献
Ketcha, Daniel M.; Gribble, Gordon W.
Journal of Organic Chemistry, 1985 , vol. 50, # 26 p. 5451 - 5457
反应条件
tetrabutylammomium bromide; potassium carbonate in acetonitrile
T=20°C; 0.333333 h;
参考文献
Venkatanarayana, Muvvala; Dubey, Pramod K.
Letters in Organic Chemistry, 2012 , vol. 9, # 3 p. 192 - 197
反应条件
1: 100 percent / pyridine / CH2Cl2 / 1.) 0 deg C, 1 h, 2.) 25 deg C, overnight
2: 81 percent / BF3*Et2O / CH2Cl2 / 1.5 h / 0 °C
3: 1.) AlCl3 / 1.) CH2Cl2, 25 deg C, 15 min, 2.) CH2Cl2, 25 deg C, 2 h
View Scheme
参考文献
Ketcha, Daniel M.; Gribble, Gordon W.
Journal of Organic Chemistry, 1985 , vol. 50, # 26 p. 5451 - 5457
反应条件
1: 100 percent / pyridine / CH2Cl2 / 1.) 0 deg C, 1 h, 2.) 25 deg C, overnight
2: 81 percent / BF3*Et2O / CH2Cl2 / 1.5 h / 0 °C
3: 1.) AlCl3 / 1.) CH2Cl2, 25 deg C, 15 min, 2.) CH2Cl2, 25 deg C, 2 h
View Scheme
参考文献
Ketcha, Daniel M.; Gribble, Gordon W.
Journal of Organic Chemistry, 1985 , vol. 50, # 26 p. 5451 - 5457
反应条件
1: 81 percent / BF3*Et2O / CH2Cl2 / 1.5 h / 0 °C
2: 1.) AlCl3 / 1.) CH2Cl2, 25 deg C, 15 min, 2.) CH2Cl2, 25 deg C, 2 h
View Scheme
参考文献
Ketcha, Daniel M.; Gribble, Gordon W.
Journal of Organic Chemistry, 1985 , vol. 50, # 26 p. 5451 - 5457
反应条件
1: propionic acid anhydride / 100 °C
2: sodium hydroxide / water / 4 h / Reflux
3: tetrabutylammomium bromide; potassium carbonate / acetonitrile / 0.33 h / 20 °C
View Scheme
参考文献
Venkatanarayana; Dubey, Pramod K.
Letters in Organic Chemistry, 2011 , vol. 8, # 9 p. 656 - 662
反应条件
1: sodium hydroxide / water / 4 h / Reflux
2: tetrabutylammomium bromide; potassium carbonate / acetonitrile / 0.33 h / 20 °C
View Scheme
参考文献
Venkatanarayana; Dubey, Pramod K.
Letters in Organic Chemistry, 2011 , vol. 8, # 9 p. 656 - 662
反应条件
1: sodium hydroxide / water / 2 h / Reflux
2: tetrabutylammomium bromide; potassium carbonate / acetonitrile / 0.33 h / 20 °C
View Scheme
参考文献
Venkatanarayana; Dubey, Pramod K.
Letters in Organic Chemistry, 2011 , vol. 8, # 9 p. 656 - 662
反应条件
aluminium trichloride
1.) CH2Cl2, 25 deg C, 15 min, 2.) CH2Cl2, 25 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Ketcha, Daniel M.; Gribble, Gordon W.
Journal of Organic Chemistry, 1985 , vol. 50, # 26 p. 5451 - 5457
