2-甲基-3-溴苯甲酸甲酯合成路线 （共 27 条）
反应条件
sulfuric acid; nitric acid in water
T=-30 - 10°C; 0.5 h;
参考文献
Curtin, Michael L.; Davidsen, Steven K.; Frey, Robin R.; Heyman, Howard R.; Holms, James H.; Michaelides, Michael; Steinman, Douglas H.
Patent: US2005/26976 A1, 2005 ;
Location in patent: Page/Page column 29 ;
US 20050026976 A1
反应条件
1: 75 percent / chromyl chloride / CCl4 / 20 h / Heating
2: 100 percent / dimethylformamide / 12 h / Heating
View Scheme
参考文献
Xiao, Xiangshu; Antony, Smitha; Pommier, Yves; Cushman, Mark
Journal of Medicinal Chemistry, 2006 , vol. 49, # 4 p. 1408 - 1412
反应条件
chromium oxychloride in tetrachloromethane
T=0°C; 23 h; Reflux;
参考文献
Zhang, Peng; Cyriac, George; Kopajtic, Theresa; Zhao, Yongfang; Javitch, Jonathan A.; Katz, Jonathan L.; Newman, Amy Hauck
Journal of Medicinal Chemistry, 2010 , vol. 53, # 16 p. 6112 - 6121
反应条件
sodium carbonate; potassium hexacyanoferrate(III); palladium diacetate in N,N-dimethyl acetamide
T=120°C; 10 h;
参考文献
Inotek Pharmaceuticals Corporation
Patent: US2007/49555 A1, 2007 ;
Location in patent: Page/Page column 94 ;
反应条件
sodium carbonate; palladium diacetate in N,N-dimethyl acetamide
T=120°C; 10 h;
参考文献
INOTEK PHARMACEUTICALS CORPORATION
Patent: WO2008/106619 A2, 2008 ;
Location in patent: Page/Page column 581 ;
反应条件
sodium carbonate; palladium diacetate in dimethyl amine
T=20 - 120°C; 22 h;
参考文献
EXELIXIS, INC.
Patent: WO2009/55077 A1, 2009 ;
Location in patent: Page/Page column 380-381 ;
反应条件
1: With sulfuric acid; nitric acid
T=-20 - 0°C; 0.5 h;
2: With hydrogenchloride; tin(ll) chloride in methanol; water
T=20°C; 4 h;
参考文献
ABBOTT LABORATORIES
Patent: WO2004/108672 A1, 2004 ;
Location in patent: Page 52; 53 ;
WO 2004/108672 A1
