2-甲基-4-溴苯甲酸甲酯合成路线 （共 26 条）
反应条件
1: aqueous ethanol; hydrazine hydrate 2: pyridine 3: ethylene glycol; Na2CO3 / 160 °C View Scheme
参考文献
Journal of the Chemical Society, , p. 690
反应条件
1.1: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / benzene / 80 °C 2.1: ammonia / methanol / 20 °C 3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / |Inert atmosphere 3.2: 1 h / 20 °C / |Inert atmosphere View Scheme
参考文献
PETER MACCALLUM CANCER INSTITUTE; SPICER, Julie Ann; DENNY, William Alexander; MILLER, Christian Karl; O'CONNOR, Patrick David; HUTTUNEN, Kristiina; TRAPANI, Joseph A.; HILL, Geoff; ALEXANDER, Kylie
Patent: WO2014/28968 A1, 2014 ;
反应条件
1.1: N-bromosuccinmide; dibenzoyl peroxide / tetrachloromethane / 4 h / 20 °C 2.1: ammonia / methanol / 0.17 h / 0 °C 2.2: 16 h / 20 °C View Scheme
参考文献
WO2011/134468 A1, ;
WO 2011/134468 A1
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=100°C; 16 h; Inert atmosphere;
参考文献
SYNGENTA PARTICIPATIONS AG; JUNG, Pierre Joseph Marcel; GODFREY, Christopher Richard Ayles; HUETER, Ottmar Franz; MAIENFISCH, Peter
Patent: WO2010/127926 A1, 2010 ;
Location in patent: Page/Page column 46 ;
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=100°C; 2 h;
参考文献
EXELIXIS, INC.
Patent: WO2009/55077 A1, 2009 ;
Location in patent: Page/Page column 430 ;
反应条件
T=180°C; 5 h; Inert atmosphere;
参考文献
F. HOFFMANN-LA ROCHE AG; AEBI, Johannes; AMREIN, Kurt; CHEN, Wenming; HORNSPERGER, Benoit; KUHN, Bernd; LIU, Yongfu; MAERKI, Hans P.; MAYWEG, Alexander V.; MOHR, Peter; TAN, Xuefei; WANG, Zhanguo; ZHOU, Mingwei
Patent: WO2013/79452 A1, 2013 ;
Location in patent: Page/Page column 165 ;
反应条件
in 1-methyl-pyrrolidin-2-one T=180°C; 5 h;
参考文献
PainCeptor Pharma Corporation
Patent: US2009/82368 A1, 2009 ;
Location in patent: Page/Page column 41-42 ;
反应条件
lithium aluminium tetrahydride in diethyl ether 3 h;
参考文献
Allergan Sales, Inc.
Patent: US6369225 B1, 2002 ;
Location in patent: Page column 43, 119 ;
反应条件
1: lithium aluminium tetrahydride / dichloromethane / 16 h / 0 - 20 °C 2: phosphorus tribromide / dichloromethane / 3 h / 0 - 20 °C View Scheme
参考文献
AFRAXIS, INC.; CAMPBELL, David; DURÓN, Sergio, G.
Patent: WO2013/43232 A2, 2013 ;
WO 2013/043232 A2
反应条件
1: 5 h / 180 °C / |Inert atmosphere 2: N-bromosuccinmide; dibenzoyl peroxide / tetrachloromethane / 3 h / |Inert atmosphere; |Reflux View Scheme
参考文献
AMGEN INC.; BISWAS, Kaustav; CHEN, Jian J.; GORE, Vijay Keshav; HARRIED, Scott; HORNE, Daniel B.; KALLER, Matthew R.; MA, Vu Van; SHAM, Kelvin; ZHONG, Wenge
Patent: US2014/45855 A1, 2014 ;
