2-溴-6-甲基苯甲酸甲酯合成路线 （共 11 条）
反应条件
1: 2-bromo-6-methylbenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=20°C; 2 h; 2: methanol
参考文献
Shionogi and Co., Ltd.
Patent: EP2455370 A1, 2012 ;
Location in patent: Page/Page column 101 ;
反应条件
1: With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=0°C; 1 - 2 h; 2: With methanol 16 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2004/89897 A1, 2004 ;
Location in patent: Page 15; 17 ;
WO 2004/089897 A1
反应条件
potassium hydrogencarbonate in N,N-dimethyl-formamide T=20°C; 16 h;
参考文献
US2008/108659 A1, ;
Page/Page column 11 ;
反应条件
1: With hydrogen bromide; sodium nitrite Sandmeyer reaction; 2: With hydrogen bromide; copper(I) bromide T=0 - 20°C;
参考文献
Pospisil, Jiri; Mueller, Christoph; Fuerstner, Alois
Chemistry - A European Journal, 2009 , vol. 15, # 24 p. 5956 - 5968
反应条件
1.1: 98 percent / K2CO3 / acetone / Heating 2.1: 100 percent / H2 / Pd/C / ethanol / 760 Torr 3.1: NaNO2; HBr 3.2: 97 percent / CuBr; HBr / 0 - 20 °C View Scheme
参考文献
Chemical Communications, , # 44 p. 5583 - 5585
反应条件
1.1: 100 percent / H2 / Pd/C / ethanol / 760 Torr 2.1: NaNO2; HBr 2.2: 97 percent / CuBr; HBr / 0 - 20 °C View Scheme
参考文献
Chemical Communications, , # 44 p. 5583 - 5585
反应条件
in methanol; diethyl ether; toluene 2 h; Inert atmosphereSchlenk technique;
参考文献
Dydio, Pawel; Reek, Joost N. H.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 14 p. 3878 - 3882
Angew. Chem., 2013 , vol. 125, # 14 p. 4132
反应条件
triethylamine T=0°C; 1 h;
参考文献
Heterocycles, , vol. 45, # 11 p. 2217 - 2221
反应条件
1: copper(I) bromide / water; hydrogen bromide 2: thionyl chloride; methanol View Scheme
参考文献
US2013/5705 A1, ;
US 20130005705 A1
参考文献
Peltier
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1954 , vol. 238, p. 357,358
Bulletin de la Societe Scientifique de Bretagne, 1956 , vol. 31, p. Sonderheft S. 9, 30
