2-溴-2-(2-甲氧基苯基)乙酸甲酯合成路线 （共 4 条）
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane
2 h; Heating / reflux;
参考文献
ABBOTT GMBH and CO. KG
Patent: WO2008/25736 A1, 2008 ;
Location in patent: Page/Page column 63 ;
WO 2008/025736 A1
反应条件
thionyl bromide in toluene
T=20°C; Bromination;
参考文献
Astles, Peter C.; Brown, Thomas J.; Halley, Frank; Handscombe, Caroline M.; Harris, Neil V.; Majid, Tahir N.; McCarthy, Clive; McLay, Lain M.; Morley, Andrew; Porter, Barry; Roach, Alan G.; Sargent, Carol; Smith, Christopher; Walsh, Roger J. A.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 5 p. 900 - 910
反应条件
1: H2SO4 / Heating
2: SOBr2 / toluene / 20 °C
View Scheme
参考文献
Astles, Peter C.; Brown, Thomas J.; Halley, Frank; Handscombe, Caroline M.; Harris, Neil V.; Majid, Tahir N.; McCarthy, Clive; McLay, Lain M.; Morley, Andrew; Porter, Barry; Roach, Alan G.; Sargent, Carol; Smith, Christopher; Walsh, Roger J. A.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 5 p. 900 - 910
反应条件
1: aq. KOH; LiCl / dioxane / 10 - 15 °C
2: H2SO4 / Heating
3: SOBr2 / toluene / 20 °C
View Scheme
参考文献
Astles, Peter C.; Brown, Thomas J.; Halley, Frank; Handscombe, Caroline M.; Harris, Neil V.; Majid, Tahir N.; McCarthy, Clive; McLay, Lain M.; Morley, Andrew; Porter, Barry; Roach, Alan G.; Sargent, Carol; Smith, Christopher; Walsh, Roger J. A.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 5 p. 900 - 910
