5-氯-2-甲基-苯甲酸甲酯合成路线 （共 7 条）
反应条件
sulfuric acid in methanol 12 h; Heating / reflux;
参考文献
PHARMACIA and UPJOHN COMPANY
Patent: WO2004/18414 A2, 2004 ;
Location in patent: Page 111 ;
反应条件
1: 5-chloro-2-methylbenzoic acid With thionyl chloride in dichloromethane T=20°C; 1 h; 2: methanol in dichloromethane 16 h; 3: methanol With pyridine in dichloromethane T=20°C; 48 h;
参考文献
SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY, INC.
Patent: WO2006/88920 A1, 2006 ;
Location in patent: Page/Page column 129-130 ;
WO 2006/088920 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C;
参考文献
WO2006/19768 A1, ;
Page/Page column 156; 158 ;
WO 2006/019768 A1
反应条件
iron (III) acetylacetonate in tetrahydrofuran; 1-methyl-pyrrolidin-2-one; toluene T=20°C; 2 h; Inert atmosphere; chemoselective reaction;
参考文献
Malhotra, Sushant; Seng, Pamela S.; Koenig, Stefan G.; Deese, Alan J.; Ford, Kevin A.
Organic Letters, 2013 , vol. 15, # 14 p. 3698 - 3701
反应条件
1: aq. HNO3, NaCl 2: H2SO4 / 1,2-dichloro-ethane View Scheme
参考文献
Israel Journal of Chemistry, , vol. 9, p. 111 - 118
反应条件
N-bromosuccinmide; azobisisobutyronitrile in anhydrous dichloroethane 2 h; Photoirradiation;
参考文献
PHARMACIA and UPJOHN COMPANY
Patent: WO2004/18414 A2, 2004 ;
Location in patent: Page 112 ;
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
T=70°C; 24 h;
参考文献
SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY, INC.
Patent: WO2006/88920 A1, 2006 ;
Location in patent: Page/Page column 130 ;
WO 2006/088920 A1
