2-氯-6-甲基苯甲酸甲酯合成路线 （共 9 条）
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane T=70°C; 24 h;
参考文献
WO2006/77414 A1, ;
Page/Page column 150 ;
WO 2006/077414 A1
反应条件
water; sodium hydroxide 21 h; Reflux;
参考文献
Daniewski, Andrzej R.; Liu, Wen; Puentener, Kurt; Scalone, Michelangelo
Organic Process Research and Development, 2002 , vol. 6, # 3 p. 220 - 224
反应条件
1: in dichloromethane
T=0°C; 0.75 h;
2: With triethylamine
T=20°C;
参考文献
X-CEPTOR THERAPEUTICS, INC.; SANKYO COMPANY, LIMITED
Patent: WO2004/58717 A1, 2004 ;
Location in patent: Page 76 ;
WO 2004/058717 A1
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide)
T=20°C; 3 h;
参考文献
Ube Industries, Ltd.
Patent: EP1408033 A1, 2004 ;
Location in patent: Page 115 ;
反应条件
1: 2-chloro-6-methyl benzoic acid With lithium hydroxide hydrate in tetrahydrofuran
T=25°C; 1 h;
2: dimethyl sulfate in tetrahydrofuran
T=25°C; 16 h; HeatingReflux;
参考文献
Gruenenthal GmbH
Patent: US2010/249095 A1, 2010 ;
Location in patent: Page/Page column 91 ;
US 20100249095 A1
反应条件
base; Pd-catalyst
T=160°C; P=30003 Torr; Inert atmosphereAutoclave;
参考文献
Daniewski, Andrzej R.; Liu, Wen; Puentener, Kurt; Scalone, Michelangelo
Organic Process Research and Development, 2002 , vol. 6, # 3 p. 220 - 224
反应条件
base; Pd-catalyst
P=30003 Torr; Inert atmosphereAutoclaveHeating;
参考文献
Daniewski, Andrzej R.; Liu, Wen; Puentener, Kurt; Scalone, Michelangelo
Organic Process Research and Development, 2002 , vol. 6, # 3 p. 220 - 224
反应条件
bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate
T=140°C; P=30003 Torr; 8 h; Inert atmosphereAutoclave; Catalytic behavior; Reagent/catalystTimeTemperatureConcentration;
参考文献
Daniewski, Andrzej R.; Liu, Wen; Puentener, Kurt; Scalone, Michelangelo
Organic Process Research and Development, 2002 , vol. 6, # 3 p. 220 - 224
反应条件
1: sodium hydroxide; water / 21 h / |Reflux
2: oxalyl dichloride / N,N-dimethyl-formamide; toluene / 1 h / 17 °C
View Scheme
参考文献
Daniewski, Andrzej R.; Liu, Wen; Puentener, Kurt; Scalone, Michelangelo
Organic Process Research and Development, 2002 , vol. 6, # 3 p. 220 - 224
