1,2,3,9-四氢-9-甲基-3-亚甲咔唑酮合成路线 （共 18 条）
反应条件
sulfuric acid in N,N-dimethyl-formamide T=10 - 115°C; 4 h;
参考文献
Gutman, Daniella; Cyjon, Rosa
Patent: US2006/41004 A1, 2006 ;
Location in patent: Page/Page column 8 ;
反应条件
hydrogenchloride; ammonium chloride in DMF (N,N-dimethyl-formamide) T=110 - 120°C; 5 - 6 h; Product distribution / selectivity;
参考文献
Gutman, Daniella; Cyjon, Rosa
Patent: US2006/41004 A1, 2006 ;
Location in patent: Page/Page column 7; 8 ;
反应条件
trifluoroacetic acid in toluene T=0°C; 24 h; Heating / reflux; Product distribution / selectivity;
参考文献
YUHAN CORPORATION
Patent: WO2005/37823 A1, 2005 ;
Location in patent: Page/Page column 10-11 ;
反应条件
1: With acetyl chloride in acetonitrile 2 h; Heating / reflux; 2: With sodium acetate in acetonitrile 6.5 h; Heating / reflux; Product distribution / selectivity;
参考文献
YUHAN CORPORATION
Patent: WO2005/37823 A1, 2005 ;
Location in patent: Page/Page column 11 ;
反应条件
paraformaldehyde in acetic acid
反应条件
1: With acetic anhydride; acetyl chloride in acetonitrile 1 h; Heating / reflux; 2: With sodium acetate in acetonitrile Heating / reflux; Product distribution / selectivity;
参考文献
YUHAN CORPORATION
Patent: WO2005/37823 A1, 2005 ;
Location in patent: Page/Page column 10 ;
反应条件
1: With acetic anhydride; acetyl chloride in acetonitrile 1 h; Heating / reflux; 2: With sodium acetate in acetonitrile Heating / reflux; Product distribution / selectivity;
参考文献
YUHAN CORPORATION
Patent: WO2005/37823 A1, 2005 ;
Location in patent: Page/Page column 10 ;
反应条件
1: With acetic anhydride; acetyl chloride in acetonitrile 1 h; Heating / reflux; 2: With sodium acetate in acetonitrile Heating / reflux; Product distribution / selectivity;
参考文献
YUHAN CORPORATION
Patent: WO2005/37823 A1, 2005 ;
Location in patent: Page/Page column 9 ;
反应条件
acetic acid in water; toluene T=100 - 105°C; 3.5 h; Product distribution / selectivity;
参考文献
WO2006/46253 A1, ;
Page/Page column 18-19 ;
反应条件
tetrabutyl ammonium fluoride in acetonitrile 2.16667 h; Heating / reflux; Product distribution / selectivity;
参考文献
WO2005/37823 A1, ;
Page/Page column 14-15 ;
