1: 1N sodium hydroxide / H2O 2: 1.) AcCl, 3.) Zn, Cu / 1.) MeOH, 2.) CH2Cl2, 3.) MeOH 3: 91 percent / dimethylformamide / 6 h / 100 °C 4: 90 percent / butylamine View Scheme

1: 90 percent / various solvent(s) / 1 h / 115 °C 2: 98 percent / AcBr, MeOH / ethyl acetate / 1 h / Heating View Scheme

1: 1N sodium hydroxide / H2O 2: 1.) AcCl, 3.) Zn, Cu / 1.) MeOH, 2.) CH2Cl2, 3.) MeOH 3: 91 percent / dimethylformamide / 6 h / 100 °C View Scheme

1: 1N sodium hydroxide / H2O 2: 1.) AcCl, 3.) Zn, Cu / 1.) MeOH, 2.) CH2Cl2, 3.) MeOH 3: 91 percent / NaOH, IPA View Scheme