3-溴-(1-苯磺酰)吲哚合成路线 （共 25 条）
反应条件
2: 95 percent / NaOH / methanol / 2 h / Heating
3: 94 percent / NaH / tetrahydrofuran / 4 h / 0 °C
View Scheme
参考文献
Claridge, Timothy D.W.; Long, James M.; Brown, John M.; Hibbs, David; Hursthouse, Michael B.
Tetrahedron, 1997 , vol. 53, # 11 p. 4035 - 4050
反应条件
aluminium trichloride in dichloromethane
参考文献
Ketcha, Daniel M.; Lieurance, Brett A.; Homan, Dominic F. J.; Gribble, Gordin W.
Journal of Organic Chemistry, 1989 , vol. 54, # 18 p. 4350 - 4356
反应条件
1: 100 percent / Na2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane; ethanol; H2O / 18 h / Heating
2: 93 percent / K2CO3 / methanol / 18 h / Heating
View Scheme
参考文献
Pathak, Rakhi; Nhlapo, Johanna M.; Govender, Sameshnee; Michael, Joseph P.; Van Otterlo, Willem A. L.; De Koning, Charles B.
Tetrahedron, 2006 , vol. 62, # 12 p. 2820 - 2830
反应条件
1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium(0) / ethylene glycol dimethyl ether / 0.25 h / 85 °C / Inert atmosphere
2: potassium carbonate; methanol / 16 h / Inert atmosphere; Reflux
View Scheme
参考文献
KARO BIO AB
Patent: US2012/202861 A1, 2012 ;
反应条件
1: 1.) a) tert-butyllithium, b) cuprous cyanide / 1.) pentane, THF-Et2O 3:1 a) -95 deg C, 6 min b) -90 deg C, 3 min, 2.) a) -95 deg C, 0.5 h, b) -78 deg C, 1 h, c) RT, 14 h
2: diisopropylamine, n-butyllithium / tetrahydrofuran; hexane / 1.5 h / -70 °C
View Scheme
参考文献
Wenkert, Ernest; Angell, E. Charles; Ferreira, Vitor F.; Michelotti, Enrique L.; Piettre, Serge R.; et al.
Journal of Organic Chemistry, 1986 , vol. 51, # 12 p. 2343 - 2351
