2,6-二溴-3,4-二氢萘-1(2H)-酮合成路线 （共 2 条）
反应条件
hydrogen bromide; bromine; acetic acid
T=10 - 20°C;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BENDER, John A.; HEWAWASAM, Piyasena; KADOW, John F.; LOPEZ, Omar D.; MEANWELL, Nicholas A.; NGUYEN, Van N.; ROMINE, Jeffrey Lee; SNYDER, Lawrence B.; ST. LAURENT, Denis R.; WANG, Gan; XU, Ningning; BELEMA, Makonen
Patent: WO2010/117635 A1, 2010 ;
Location in patent: Page/Page column 81-82 ;
WO 2010/117635 A1
反应条件
1.1: sodium nitrite; hydrogen bromide / water / 1 h / 5 °C
1.2: 3 h / 20 °C
2.1: bromine; hydrogen bromide / dichloromethane / 2 h / 20 °C
View Scheme
参考文献
PRESIDIO PHARMACEUTICALS, INC.; LI, Leping; ZHONG, Min
Patent: WO2011/156543 A2, 2011 ;
WO 2011/156543 A2
