3-氯-6-(4-硝基苯基)哒嗪合成路线 （共 4 条）
反应条件
hydrogen; sodium acetate; acetic acid; palladium on activated charcoal in ethanol T=50°C;
参考文献
Shkurko, O. P.; Kuznetsov, S. A.; Denisov, A. Yu.; Mamaev, V. P.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1986 , vol. 22, # 7 p. 763 - 770
Khimiya Geterotsiklicheskikh Soedinenii, 1986 , vol. 22, # 7 p. 951 - 958
反应条件
sulfuric acid; nitric acid in water
T=0°C; 0.25 h;
参考文献
Basha, Anwer; Bunnelle, William H.; Dart, Michael J.; Gallagher, Megan E.; Ji, Jianguo; Li, Tao; Pace, Jennifer M.; Ryther, Keith B.; Tietje, Karin R.; Mortell, Kathleen H.; Nersesian, Diana L.; Schrimpf, Michael R.
Patent: US2005/101602 A1, 2005 ;
Location in patent: Page/Page column 43-44 ;
反应条件
1: 50 percent / 16 h / 135 °C
2: 88 percent / hydrazine hydrate / butan-1-ol / 8 h / Heating
3: phosphorus oxychloride / 4 h / 85 - 95 °C
View Scheme
参考文献
Wermuth, Camille-Georges; Bourguignon, Jean-Jacques; Schlewer, Gilbert; Gies, Jean-Pierre; Schoenfelder, Angele; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 239 - 249
反应条件
1: 88 percent / hydrazine hydrate / butan-1-ol / 8 h / Heating
2: phosphorus oxychloride / 4 h / 85 - 95 °C
View Scheme
参考文献
Wermuth, Camille-Georges; Bourguignon, Jean-Jacques; Schlewer, Gilbert; Gies, Jean-Pierre; Schoenfelder, Angele; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 239 - 249
