3-(Boc-氨基)吡咯烷合成路线 （共 7 条）
反应条件
hydrogen; palladium 10 on activated carbon in tetrahydrofuran; methanol 12 h;
参考文献
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; CRYSTALGENOMICS, INC.
Patent: WO2007/52938 A1, 2007 ;
Location in patent: Page/Page column 23 ;
WO 2007/052938 A1
反应条件
potassium hydroxide in methanol T=15 - 20°C; pH=11.8 - 12.2; 1 h;
参考文献
EP1460061 A1, ;
Page 5-6 ;
反应条件
triethylamine in acetonitrile 1.) reflux, 3 h, 2.) room temperature, 18 h;
参考文献
Warner-Lambert Company
Patent: US4885386 A1, 1989 ;
反应条件
sodium periodate; potassium carbonate; OsO4; Pd(PPh3)4 in acetone-water; CH2CI2; CICH2CH2CI; water; N,N-dimethyl-formamide
参考文献
SCHERING CORPORATION
Patent: US2003/92715 A1, 2003 ;
US 20030092715 A1
反应条件
1: N,N-diisopropylethylamine / acetonitrile / 14 h / Heating 2: H2 / Ra-Ni / tetrahydrofuran / 5 h / 20 °C / 2585.74 Torr View Scheme
参考文献
VanderWel, Scott N.; Harvey, Patricia J.; McNamara, Dennis J.; Repine, Joseph T.; Keller, Paul R.; Quin III, John; Booth, R. John; Elliott, William L.; Dobrusin, Ellen M.; Fry, David W.; Toogood, Peter L.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2371 - 2387
反应条件
sodium tris(acetoxy)borohydride in water; 1,2-dichloro-ethane
T=20°C; 2 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2010/261714 A1, 2010 ;
Location in patent: Page/Page column 70 ;
反应条件
1: With sodium cyanoborohydride; acetic acid in methanol
18 h;
2: With water in methanol
T=0°C;
参考文献
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; CRYSTALGENOMICS, INC.
Patent: WO2007/52938 A1, 2007 ;
Location in patent: Page/Page column 23-24 ;
WO 2007/052938 A1
