5-溴-2-氟-1,3-二甲苯合成路线 （共 3 条）
反应条件
HBF4; sodium nitrite in starch iodide; water
参考文献
Merck and Co., Inc.
Patent: US6013652 A1, 2000 ;
US 6013652 A
Title/Abstract Full Text Show Details
Merck and Co., Inc.
Patent: US5962462 A1, 1999 ;
US 5962462 A
反应条件
hydrogen fluoride; sodium nitrite 1.) H2O, EtOH, 5 deg C, 1 h, 2.) from 110 deg C to 200 deg C, 1.5 h; Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 2 p. 170 - 181
反应条件
in DMF (N,N-dimethyl-formamide)
T=20 - 50°C; 8 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/9086 A1, 2004 ;
Location in patent: Page/Page column 87 ;
WO 2004/009086 A1
