反应条件
1: trifluoroacetic anhydride, Me2SO / CH2Cl2 / 0.5 h / -78 °C
2: 55 percent / hydrazine, KOH / bis-(2-hydroxy-ethyl) ether / 15 h / 200 - 205 °C
3: 1.) N-chlorosuccinimide, 2.) CuBr2, CuO / 1.) CCl4, 0 deg C, 4 h, 2.) THF, H2O, reflux, 10 min
View Scheme
参考文献
Stokker, G. E.; Alberts, A. W.; Anderson, P. S.; Cragoe, E. J.; Deana, A. A.; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 2 p. 170 - 181
