(1'R,3r)-(+)-1-(1'-苯基乙基)-5-氧代-3-吡咯烷羧酸合成路线 (共 6 条)
反应条件
in 1,3-dimethyl-imidazolidin-2-one T=120°C; 14 h;
参考文献
ASTRAZENECA AB
Patent: US2011/92526 A1, 2011 ;
Location in patent: Page/Page column 24 ;
反应条件
hydrogenchloride T=100°C; 3 h;
参考文献
Culbertson, Townley P.; Domagala, John M.; Nichols, Jeffery B.; Priebe, Stephen; Skeean, Richard W.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1711 - 1715
反应条件
1: 34 percent / 4A sieves / toluene / Ambient temperature 2: 70 percent / 6 N aq. HCl / 3 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 10 p. 1711 - 1715
反应条件
1: 34 percent / 4A sieves / toluene / Ambient temperature 2: 70 percent / 6 N aq. HCl / 3 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 10 p. 1711 - 1715
反应条件
1: 41 percent / p-TsOH / 24 h / Heating 2: 70 percent / 6 N aq. HCl / 3 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 10 p. 1711 - 1715
反应条件
in xylene 24 h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 10 p. 1711 - 1715