(R)-5-氧代-1-((r)-1-苯基乙基)吡咯烷-3-羧酸甲酯合成路线 （共 8 条）
反应条件
hydrogenchloride T=100°C; 3 h;
参考文献
Culbertson, Townley P.; Domagala, John M.; Nichols, Jeffery B.; Priebe, Stephen; Skeean, Richard W.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1711 - 1715
反应条件
LiAlH in tetrahydrofuran 24 h; Heating;
参考文献
Culbertson, Townley P.; Domagala, John M.; Nichols, Jeffery B.; Priebe, Stephen; Skeean, Richard W.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1711 - 1715
反应条件
1: in methanol
T=20°C; 18 h;
2: With toluene-4-sulfonic acid in toluene
16 h; Reflux;
参考文献
MITSUBISHI TANABE PHARMA CORPORATION; SANOFI-AVENTIS; NAKAYAMA, Kazuki; SAKAI, Daiki; WATANABE, Kazutoshi; KOHARA, Toshiyuki; ARITOMO, Keiichi
Patent: WO2011/19090 A1, 2011 ;
Location in patent: Page/Page column 44-45 ;
WO 2011/019090 A1
反应条件
4 A molecular sieve in toluene
Ambient temperature;
参考文献
Culbertson, Townley P.; Domagala, John M.; Nichols, Jeffery B.; Priebe, Stephen; Skeean, Richard W.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1711 - 1715
反应条件
toluene-4-sulfonic acid
24 h; Heating;
参考文献
Culbertson, Townley P.; Domagala, John M.; Nichols, Jeffery B.; Priebe, Stephen; Skeean, Richard W.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1711 - 1715
反应条件
1: 97 percent / 4 h / 160 °C
2: acetyl chloride / 16 h / Heating
View Scheme
参考文献
Nielsen, Lone; Brehm, Lotte; Krogsgaard-Larsen, Povl
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 71 - 77
反应条件
1: 97 percent / 4 h / 160 °C
2: acetyl chloride / 16 h / Heating
View Scheme
参考文献
Nielsen, Lone; Brehm, Lotte; Krogsgaard-Larsen, Povl
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 71 - 77
反应条件
1: 80 percent / lithium aluminum hydride / diethyl ether / 3.5 h / Heating
2: 98 percent / thionyl chloride / CHCl3 / 2 h / Heating
3: 60 percent / tricaprylmethylammonium chloride / H2O / 48 h / 100 °C
4: 42 percent / conc. hydrochloric acid / 5 h / Heating
5: H2 / 5percent Pd-C / H2O / 2205.2 Torr
View Scheme
参考文献
Nielsen, Lone; Brehm, Lotte; Krogsgaard-Larsen, Povl
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 71 - 77
