((R)-1-((r)-1-苯基乙基)吡咯烷-3-基)甲醇合成路线 （共 9 条）
反应条件
LiAlH in tetrahydrofuran 24 h; Heating;
参考文献
Culbertson, Townley P.; Domagala, John M.; Nichols, Jeffery B.; Priebe, Stephen; Skeean, Richard W.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1711 - 1715
反应条件
1: 41 percent / p-TsOH / 24 h / Heating 2: 87 percent / LiAlH / tetrahydrofuran / 24 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 10 p. 1711 - 1715
反应条件
1: 34 percent / 4A sieves / toluene / Ambient temperature 2: 87 percent / LiAlH / tetrahydrofuran / 24 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 10 p. 1711 - 1715
反应条件
1: 34 percent / 4A sieves / toluene / Ambient temperature 2: 87 percent / LiAlH / tetrahydrofuran / 24 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 10 p. 1711 - 1715
反应条件
1: 97 percent / 4 h / 160 °C 2: acetyl chloride / 16 h / Heating 3: 80 percent / lithium aluminum hydride / diethyl ether / 3.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 1 p. 71 - 77
反应条件
1: 97 percent / 4 h / 160 °C 2: acetyl chloride / 16 h / Heating 3: 80 percent / lithium aluminum hydride / diethyl ether / 3.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 1 p. 71 - 77
反应条件
hydrogen; palladium hydroxide - carbon in methanol; water P=2068.59 Torr; 2 h;
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 4 p. 677 - 690
反应条件
1: 98 percent / thionyl chloride / CHCl3 / 2 h / Heating
2: 60 percent / tricaprylmethylammonium chloride / H2O / 48 h / 100 °C
3: 42 percent / conc. hydrochloric acid / 5 h / Heating
4: H2 / 5percent Pd-C / H2O / 2205.2 Torr
View Scheme
参考文献
Nielsen, Lone; Brehm, Lotte; Krogsgaard-Larsen, Povl
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 71 - 77
