亮氨酰-丝氨酸对硝基-苯丙氨酰-Nle-丙氨酰-亮氨酸甲酯三氟乙酸合成路线 （共 22 条）
反应条件
potassium carbonate; sodium iodide in dichloromethane; N,N-dimethyl-formamide; trifluoroacetic acid
参考文献
Urbanski, Maud J.; Gunnet JR., Joseph W.; Demarest, Keith T.
Patent: US2003/73842 A1, 2003 ;
US 20030073842 A1
反应条件
trifluoroacetic acid in water; N,N-dimethyl-formamide; acetonitrile
参考文献
The DuPont Merck Pharmaceutical Company
Patent: US5750088 A1, 1998 ;
反应条件
trifluoroacetic acid in N,N-dimethyl-formamide; acetonitrile
参考文献
The Dupont Merck Pharmaceutical Company
Patent: US5879657 A1, 1999 ;
反应条件
trifluoroacetic acid in 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran
参考文献
Aventis Pharmaceuticals Inc.
Patent: US6541505 B1, 2003 ;
US 6541505 B1
反应条件
trifluoroacetic acid in dichloromethane
参考文献
Kanebo, Ltd
Patent: US5919769 A1, 1999 ;
反应条件
4-methyl-morpholine; LiOH; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate in tetrahydrofuran; water; N,N-dimethyl-formamide
参考文献
GENENTECH, INC.
Patent: US2002/35104 A1, 2002 ;
反应条件
N-ethyl-N,N-diisopropylamine; trifluoroacetic acid in dichloromethane; water; ethyl acetate; acetonitrile
参考文献
Merck and Co., Inc.
Patent: US5968938 A1, 1999 ;
US 5968938 A
反应条件
benzotriazol-1-ol; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine in water; N,N-dimethyl-formamide; acetonitrile
参考文献
Merck and Co., Inc.
Patent: US5968938 A1, 1999 ;
US 5968938 A
反应条件
N-ethyl-N,N-diisopropylamine; trifluoroacetic acid in methanol; water; ethyl acetate; acetonitrile
参考文献
Merck and Co., Inc.
Patent: US5968938 A1, 1999 ;
US 5968938 A
反应条件
acetic anhydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid in dichloromethane; ethyl acetate
参考文献
Merck and Co., Inc.
Patent: US5968938 A1, 1999 ;
US 5968938 A
