2-氨基-1,9-二氢-9-(4-羟基-3-(羟基甲基)-2-丁烯基)-6H-嘌呤-6-酮合成路线 （共 4 条）
反应条件
sodium hydroxide; boron trichloride
1.) CH2Cl2, -78 deg C, 15 h, 2.) 80 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Haines, David R.; Tseng, Christopher K. H.; Marquez, Victor E.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 943 - 947
反应条件
1: 54 percent / K2CO3 / dimethylsulfoxide / 4 h / Ambient temperature
2: 1.) BCl3, 2.) aq. NaOH / 1.) CH2Cl2, -78 deg C, 15 h, 2.) 80 deg C, 2 h
View Scheme
参考文献
Haines, David R.; Tseng, Christopher K. H.; Marquez, Victor E.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 943 - 947
反应条件
1: 35 percent / cesium carbonate / dimethylformamide / 20 °C
2: 78 percent / aq. HCl / 4 h / Heating
View Scheme
参考文献
Hong, Joon; Kim, So-Young; Oh, Chang-Hyun; Yoo, Kyung; Cho, Jung-Hyuck
Nucleosides, Nucleotides and Nucleic Acids, 2006 , vol. 25, # 3 p. 341 - 350
反应条件
1: 79 percent / triphenylphosphine; N-bromosuccinimide / CH2Cl2 / 4 h / 20 °C
2: 35 percent / cesium carbonate / dimethylformamide / 20 °C
3: 78 percent / aq. HCl / 4 h / Heating
View Scheme
参考文献
Hong, Joon; Kim, So-Young; Oh, Chang-Hyun; Yoo, Kyung; Cho, Jung-Hyuck
Nucleosides, Nucleotides and Nucleic Acids, 2006 , vol. 25, # 3 p. 341 - 350
