(R)-5-(羟基甲基)-3-苯基噁唑啉-2-酮合成路线 （共 3 条）
反应条件
caesium carbonate in N,N-dimethyl-formamide
T=80 - 90°C; 3 h;
参考文献
Ganguly, A.K.; Biswas, Dipshikha; Alluri, Sesha Sridevi; Caroccia, Danielle; Wang, Chih-Hung; Kang, Eun Hee
Patent: US2011/112068 A1, 2011 ;
Location in patent: Page/Page column 43 ;
US 20110112068 A1
反应条件
1.1: NaHCO3 / acetone; H2O / 20 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 0.75 h / -78 °C
2.2: tetrahydrofuran; hexane / -78 - 20 °C
View Scheme
参考文献
Ali, Akbar; Reddy, G. S. Kiran Kumar; Cao, Hong; Anjum, Saima Ghafoor; Nalam, Madhavi N. L.; Schiffer, Celia A.; Rana, Tariq M.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7342 - 7356
反应条件
2: lipoprotein lipase, sodium hydroxyde / various solvent(s) / 6 h
View Scheme
参考文献
Hamaguchi, Shigeki; Yamamura, Hiroshi; Hasegawa, Junzo; Watanabe, Kiyoshi
Agricultural and Biological Chemistry, 1985 , vol. 49, # 5 p. 1509 - 1512
