8-甲基-3-亚甲基-8-氮杂-双环[3.2.1]辛烷合成路线 (共 2 条)
反应条件
potassium tert-butylate
1.) THF, 15 h, 2.) THF, 15 h; Yield given. Multistep reaction;
参考文献
Spanka, Gerhard; Rademacher, Paul
Journal of Organic Chemistry, 1986 , vol. 51, # 5 p. 592 - 596
反应条件
sodium hydroxide in 1,4-dioxane; water
T=105°C; 82.5 h; or (i-Pr)2NEt; other reaction temperatures and times, ΔH(excit.), ΔS(excit.); Rate constantThermodynamic data;
参考文献
Murr, Brown L.; Parkhill, Billy J.; Nickon, Alex
Tetrahedron, 1992 , vol. 48, # 23 p. 4845 - 4862